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Gener som påverkar risken för Alzheimers sjukdom
Man har sett minst 21 riskgener som har betydelse för uppkomsten av Alzheimers sjukdom.
Den av störst betydelse är genen apolipoprotein E, ApoE.
Personer som bär en varianter av genen ApoE, den s k ApoE4-allelen, (epsilon)4-allelen i (APOE) har en förhöjd risk på mellan 1,5 till 10 gånger för Alzheimers sjukdom och lägre debutålder jämfört med risken i den allmänna befolkningen. Associationen har bekräftats otaliga gånger och visar att ca 20 procent av all alzheimer kan härledas till APOE (epsilon)4.