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Forskare har hittat fyra gener hos mÃ¤nniskan dÃ¤r en viss variant Ã¶kar risken fÃ¶r tvÃ¥ngssyndrom, OCD (obsessive compulsive disorder).
Tidigare genetiska studier pÃ¥ hund har identifierat mutationer som leder till skillnader i synapsens bindning och funktion genom mutationer till exempel i generna neural cadherin (CDH2) och catenin alpha 2 (CTNNA2)
Det visade sig att de gener som kan kopplas till OCD hos hundar ocksÃ¥ har en stÃ¶rre mÃ¤ngd mutationer i mÃ¤nniskor med OCD.
TvÃ¥ gener, NRXN1 och HTR2A, uppvisade fÃ¶rÃ¤ndringar hos mÃ¤nniskor med tvÃ¥ngssyndrom, medan tvÃ¥ andra gener, CTTNBP2 och REEP3, har mutationer som pÃ¥verkar hur mycket protein som bildas utifrÃ¥n den aktuella genen.
Studiens resultat antyder att det frÃ¤mst Ã¤rÂ fÃ¶rÃ¤ndringarÂ i synapserna i en del av hjÃ¤rnan som kallas striatum, dÃ¤r bland annat planering av rÃ¶relser sker, hos mÃ¤nniskor precis som hos hundar.
Ã¤r dessutom ett mÃ¶jligt mÃ¥l fÃ¶r .
En av de fyra generna,Â HTR2A pÃ¥verkar signalÃ¤mnet seretonin i hjÃ¤rnan och skulle kunna fÃ¶rklara att vissa personer med OCD fÃ¥r lindring av serotoninÃ¥terupptagshÃ¤mmare, mediciner som pÃ¥verkar mÃ¤ngden seretonin i hjÃ¤rnans synapser.